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KMID : 0378019890320120091
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New Medical Journal
1989 Volume.32 No. 12 p.91 ~ p.94
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Clinical Study of Augmentin^(®) Prophylaxis in Abdominal Surgery
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Abstract
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It is well accepted that antibiotic prophylaxis reduces the incidence of postoperative complications following surgery on the gastro-intestinal tract.
Clean-contaminated surgery constitutes the only clear cut indication for prophylaxis.
Augmentin®, clavulanate potentiated Amoxycillin, has a particularly wide spectrum of activity against both aerobes and anaerobes and therefore offers the potential of being an effective prophylactic agent for use in abdominal surgery. Clavulanic acid is produc °d by fermentation of streptomyces clavuligerus and is an irreversible inhibitor of beta-lactamases responsible for resistance to beta-lactam antibiotics in the majority of clinically important infections and when used in combination with Amoxycillin extends its spectrum to include those organisms potentially pathogenic in the surgical situation including the commonly isolated anaerobe, Bacteroides fragilis.
This is a prospective, study in which Augmentin® givenin a three dose regime over a period of 18 hours is compared to triple therapy of Cetri®, Neticin® and Flagyl® given over 5 days.
50 patients were selected at random in each group who required elective and emergency abdominal surgery classified as clean-contaminated.
The results were ;
1. Between -two groups, there was no significant difference in the incidence of the :omplications-pyrexia, wound infection, abdominal infection and other respiratory or urinary tract infections.
2. Compared to triple therapy over 5 days, Augmentin® prophylaxis was convenient for N administration and reduced the economic burdon to patients. And it had another advantage in reducing the side effects of combination therapy of antibiotics.
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